Administration of immunoglobulins

What are immunoglobulins and why they are necessary:
Immunoglobulins are produced by B lymphocytes in our body and form our natural defense against pathogenic microorganisms such as bacteria and viruses. They also help if our body has developed autoantibodies, that is, some autoimmune disease (e.g. idiopathic thrombocytopenic purpura). In this case they bind them and can thus be expelled from the circulatory system. The immunoglobulins administered are of human origin and include the immunoglobulin M and G.

Why do I need immunoglobulins?
Immunoglobulins are administered in the following cases:
    • Primary lack of immunoglobulins in several syndromes (congenital agamma-and hypogammaglobulinaemia) or secondary immunodeficiency (hematological conditions with hypogammaglobulinaemia, history of malignancy, bone marrow transplantation).
    • Immunomodulatory effect in autoimmune diseases (eg. idiopathic thrombocytopenic purpura).

Important questions:
Please answer the following questions carefully to assess possible risk factors:
  1. Have you had an allergic reaction to immunoglobulins in the past?               
  2. Do you have a history of asthma, eczema or other allergies?                            
  3. Are you taking any medication on a daily basis?                                      
  4. Could you be or trying to get pregnant?                                                               
How are immunoglobulins administered?
The administration of immunoglobulins is through an intravenous line and is usually repeated at a dose to be determined by the doctor (5-120 gr.). The administration of immunoglobulins does not completely exclude the occurrence of seasonal infections. Their success rate in autoimmune diseases is not additive.

Possible risks or side effects:
The most important risk of immunoglobulins is the small chance of an allergic reaction, which may, in rare cases, be threatening. In rare cases vomiting, hypotension, tachycardia, fever rash, itchiness, headache, dizziness may occur. You are also likely to experience pain and sensitivity at the injection site. You will be carefully monitored by our nursing staff for any signs of these side effects.
On the day of immunoglobulin administration, you can eat your breakfast / lunch and take your medication. You can drive home after the infusion and get back to your everyday routine activities.